Polymorphonuclear leukocytes increase glomerular albumin permeability via hypohalous acid
نویسندگان
چکیده
منابع مشابه
Antibodies to protein tyrosine phosphatase receptor type O (PTPro) increase glomerular albumin permeability (P(alb)).
Glomerular capillary filtration barrier characteristics are determined in part by the slit-pore junctions of glomerular podocytes. Protein tyrosine phosphatase receptor-O (PTPro) is a transmembrane protein expressed on the apical surface of podocyte foot processes. Tyrosine phosphorylation of podocyte proteins including nephrin may control the filtration barrier. To determine whether PTPro acti...
متن کاملPolymorphonuclear Leukocytes
Complete protection of Staphylococcus aureus Wood 46 from gentamicin bactericidal activity was documented for microorganisms located within polymorphonuclear leukocytes. The highest, still ineffective gentamicin concentration tested in the phagocytic assay was 80 times higher than the minimal concentration required to kill uningested organisms. Extracellular gentamicin activity was unaffected b...
متن کاملHuman Polymorphonuclear Leukocytes
A B S T R A C T Acetyl glyceryl ether phosphorylcholine (AGEPC) and leukotriene B4 (LTB4) induce concentration-dependent neutrophil aggregation. On a molar basis, LTB4 is 10 to 100 times more potent than AGEPC. AGEPC-induced aggregation is attenuated by two inhibitors of arachidonate lipoxygenation, eicosatetraynoic acid and nordihydroguaiaretic acid, and to a lesser extent by the cyclooxygenas...
متن کاملPhagocytosing Polymorphonuclear Leukocytes
A B S T R A C T Human polymorphonuclear leukocytes (PMN) phagocytosing opsonized antigen-antibody complexes, produce dialyzable species of activated oxygen which are capable of partially suppressing the elastase-inhibiting capacity (EIC) of whole human serum or purified human a1-proteinase inhibitor. Serum EIC was partially protected by superoxide dismutase, catalase, or mannitol, suggesting th...
متن کاملChemotaxis by polymorphonuclear leukocytes
The ability of a cell or organism to direct its movement along a chemical gradient has fascinated biologists for over 100 yr. This process of chemotaxis requires transformation of directional information from the environment into a series of cellular responses resulting in directional movement. Many lower organisms including bacteria, protozoa, and slime molds exhibit chemotaxis. This ability h...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Kidney International
سال: 1994
ISSN: 0085-2538
DOI: 10.1038/ki.1994.363